Mitochondrial ROS versus ER ROS: Which Comes First in Myocardial Calcium Dysregulation?
نویسندگان
چکیده
منابع مشابه
Mitochondrial ROS versus ER ROS: Which Comes First in Myocardial Calcium Dysregulation?
Cardiomyocyte excitation–contraction coupling is tightly regulated through coordinated calcium release and uptake that is facilitated by two proteins in the sarco/endoplasmic reticulum (SR/ER) membrane, the ryanodine receptor (Ryr), and the sarco/endoplasmic reticulum Ca2+-ATPase (SERCA), respectively. Dysregulated calcium handling is a hallmark in cardiac dysfunction (1–3). Our understanding o...
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ژورنال
عنوان ژورنال: Frontiers in Cardiovascular Medicine
سال: 2016
ISSN: 2297-055X
DOI: 10.3389/fcvm.2016.00036